Last Publication
Guidotti L.G., Iannacone M.
Effector CD8 T cell trafficking within the liver
Molecular Immunology, doi:10.1016/j.molimm.2012.10.032
Jung Hwan Sung, Han Zhang, E. Ashley Moseman, David Alvarez, Matteo Iannacone, Sarah E. Henrickson, Juan C. de la Torre, Joanna R. Groom, Andrew D. Luster, Ulrich H. von Andrian
Chemokine Guidance of Central Memory T Cells Is Critical for Antiviral Recall Responses in Lymph Nodes
Cell 150, 1249–1263, September 14, 2012
Sitia, G., Aiolfi R., Di Lucia P., Mainetti M., Fiocchi A., Mingozzi F., Esposito A., Ruggeri Z.M., Chisari F.V., Iannacone M., Guidotti L.G. 2012
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Proc Natl Acad Sci USA, doi:10.1073/pnas.1209182109 (highlighted in PNAS, Nat Rev Gastroenterology & Hepatology)
See Comment in
Maini, M. K. & Schurich, A. Platelets harness the immune response to drive liver cancer.
Greenhill, C. Hepatocellular carcinoma: Could antiplatelet drugs be used to prevent HBV-associated hepatocellular carcinoma?
Nat Rev Gastroenterol Hepatol 1–1 (2012).doi:10.1038/nrgastro.2012.139
Moseman E.A.*, Iannacone M.*§, Bosurgi L., Tonti E., Chevrier N., Tumanov A., Fu X.Y., Hacohen N., von Andrian U.H.§ 2012
B Cell Maintenance of Subcapsular Sinus Macrophages Protects against a Fatal Viral Infection Independent of Adaptive Immunity
Immunity, 36:415
* equal contribution, §corresponding author
See Comment in
Science – Beyond Antibodies, ScienceNOW
Nat Rev Immunol (.pdf)
Immunity (.pdf)
SciBX (.pdf)
Tonti E., Fedeli M., Napolitano A., Iannacone M., von Andrian U.H., Guidotti L.G., Abrignani S., Casorati G., Dellabona P. 2012
Follicular Helper NKT Cells Induce Limited B Cell Responses and Germinal Center Formation in the Absence of CD4+ T Cell Help
The Journal of Immunology, 188:3217
Chevrier, N. et al. 2011
Systematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits
Cell 147, 853–867 (2011)
Sitia G.*§, Iannacone M.*§, Aiolfi R., Isogawa M., van Rooijen N., Scozzesi C., Bianchi M.E., von Andrian U.H., Chisari F.V and Guidotti L.G.§ 2011
Kupffer Cells Hasten Resolution of Liver Immunopathology in Mouse Models of Viral Hepatitis
PLoS Pathogens, June 2011. Vol 7:6
* equal contribution – § corresponding author
Iannacone M.*, Moseman E.A., Tonti E., Bosurgi L., Henrickson S.E., Whelan S., Guidotti L.G. and von Andrian U.H.* 2010
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
Nature, 465:1079 (comment in Nat Rev Immunol 2010;10:538)
*corresponding author
Iannacone M.*, Sitia G. and Guidotti L.G.* 2009
On the role of platelets in the pathogenesis of viral hepatitis
J Hepatol, 51:593
*corresponding author
Iannacone M., Sitia G., Isogawa M., Whitmire J.K., Marchese P., Chisari F.V., Ruggeri Z.M. and Guidotti L.G. 2008
Platelets prevent IFN-ab-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus
PNAS, 105:631 (selected by Faculty of 1000 Biology)
Junt T., Moseman E.A., Iannacone M., Massberg S., Lang P.A., Boes M., Fink K., Henrickson S., Shayakhmetov D.M., van Rooijen N., Mempel T., Whelan S. and von Andrian U.H. 2007
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
Nature, 450:110 (comment in Cell 2007;131:641)
Iannacone M., Sitia G., Narvaiza I., Ruggeri Z.M. and Guidotti L.G. 2007
Antiplatelet Drug Therapy Moderates Immune-Mediated Liver Disease and Inhibits Viral Clearance in Mice Infected with a Replication-Deficient Adenovirus
Clin Vaccine Immunol, 14:1532
Nascimbene A., Iannacone M., Brando B., De Gasperi A. 2007
Acute thrombocytopenia after liver transplant: Role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment
J Hepatol, 47:651 (comment in Liver Transpl. 2007;13:1753 and in J Hepatol 2007;47:625)
Iannacone M., Sitia G., Ruggeri Z.M. and Guidotti L.G. 2007
BV pathogenesis in animal models: recent advances on the role of platelets
J Hepatol 46:719
Sitia G.*, Iannacone M.*, Muller S., Bianchi M.E. and Guidotti L.G. 2007
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
J Leuk Biol 81:100
*equal contribution
Iannacone M., Sitia G. and Guidotti L.G. 2006
Pathogenetic and antiviral immune responses against Hepatitis B virus
Future Virology 1:189
Iannacone M., Sitia G., Isogawa M., Marchese P., Castro M.G., Lowenstein P.R., Chisari F.V., Ruggeri Z.M. and Guidotti L.G. 2005
Platelets mediate cytotoxic T lymphocytes-induced liver damage
Nat Med 11:1167
Sitia G., Iannacone M., Chisari F.V. and Guidotti L.G. 2005
Pathogenesis of Hepatitis B Virus in Transgenic Mice
In Models of viral hepatitis, Vol. 25. F. F. von Weizsacker, and M. E. Roggendorf, eds. Karger, Basel, Switzerland, p. 25
Sitia G., Isogawa M., Iannacone M., Campbell I.L., Chisari F.V. and Guidotti L.G. 2004
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs
J Clin Invest 113:1158
Rovere-Querini P., Capobianco A., Scaffidi P., Valentinis B., Catalanotti F., Giazzon M., Dumitriu I.E., Muller S., Iannacone M., Traversari C., Bianchi M.E. and Manfredi A.A. 2004
HMGB1 is an endogenous immune adjuvant released by necrotic cells
EMBO Rep 5:825
Mauvais-Jarvis, F., Ueki K., Fruman D.A., Hirshman M.F., Sakamoto K., Goodyear L.J., Iannacone M., Accili D., Cantley L.C., and Kahn C.R. 2002
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes
J Clin Invest 109:141
Manfredi A.A., Iannacone M., D’Auria F. and Rovere-Querini P. 2002
The disposal of dying cells in living tissues
Apoptosis 7:153
Bondanza, A., Manfredi A.A., Zimmermann V.S., Iannacone M., Tincani A., Balestrieri G., Sabbadini M.G. and Querini P.R. 2001
Anti-beta2 glycoprotein I antibodies cause inflammation and recruit dendritic cells in platelet clearance
Thromb Haemost 86:1257
Patents
- Vaccine nanotechnology
United States Patent Application 20100233251 - Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen
United States Patent Application 20100183727 - Adjuvant Incorporation in Immunonanotherapeutics
United States Patent Application 20100129439 - Targeting of Antigen Presenting Cells with Immunonanotherapeutics
United States Patent Application 20100129392 - Nicotine Immunonanotherapeutics
United States Patent Application 20100092425 - Vaccines comprising bisphosphonates and methods of use thereof
Provisional Patent Application No.: 61/405,777