MATTEO IANNACONE

MD, PhD

Head of research Unit
San Raffaele Scientific Institute

Via Olgettina 58 - 20132, Milan, Italy 

ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Researcher ID: I-8507-2018
Google Scholar: http://tiny.cc/4pibcz
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EDUCATION
 
2011

PhD

PhD IN IMMUNOLOGY

Vita-Salute San Raffaele University, Milan, Italy

2007

EUROPEAN BOARD CERTIFICATION IN INTERNAL MEDICINE 

2001

M.D.

M.D. DEGREE

University of Milan, Italy

positions and training
2015-present

Head

HEAD OF RESEARCH UNIT

San Raffaele Scientific Institute, Milan, Italy

2010-2015

Group Leader

GROUP LEADER

San Raffaele Scientific Institute, Milan, Italy

2007-2010

Postdoc

POSTDOCTORAL FELLOW

Harvard Medical School, Boston, MA

Advisor: Uli Von Andrian

2002-2006

Postdoc

POSTDOCTORAL FELLOW

The Scripps Research Institute, La Jolla, CA

Advisors: Luca Guidotti and Frank Chisari

HONORS AND AWARDS

ERC panel member for Starting Grants LS6 "Immunity, Infection and Immunothepary" (2020)

Best 2019 Publication Award from the Italian Association for the Study of the Liver (AISF)

Chiara D'Onofrio Award (2017)

European Research Council (ERC) Consolidator Grant (2016)

EMBO Young Investigator Award (2016)

European Association for the Study of the Liver (EASL) Young Investigator Award (2015)

ERC Starting Grant (2011)

Armenise-Harvard Foundation Career Development Award (2010)

Armenise-Harvard Foundation Postdoctoral Fellowship (2008)

administrative and institutional responsabilities
2014-present

DIRECTOR OF INTRAVITAL IMAGING FACILITY

San Raffaele Scientific Institute, Milan, Italy

2014-present

IMMUNOLOGY SEMINAR SERIES ORGANIZING COMMITTEE

San Raffaele Scientific Institute, Milan, Italy

2015-present

EXTERNAL SEMINAR COMMITTEE

San Raffaele Scientific Institute, Milan, Italy

2020-present

COMMITTEE FOR APPOINTMENT AND PROMOTION

San Raffaele Scientific Institute, Milan, Italy

2017-2019

SCIENTIFIC BOARD

PhD program in Molecular Medicine, Vita-Salute San Raffaele University, Milan, Italy

PROFESSIONAL ACTIVITIES
JOURNAL REVIEWER

Nature, Science, Cell, Nature Medicine, Immunity, Nature Immunology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology.

SCIENTIFIC ADVISORY BOARD

Department of Immunology, Institut Pasteur (2019), Hepatitis B program, Gilead Sciences (2020 – present.

CONFERENCE ORGANIZATION

1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1stEMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rdInternational Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2020); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Milan, Italy (2021).

GRANT REVIEWER

European Research Council (ERC), UK Medical Research Council (MRC), European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM, Panel Member for the ATIP-AVENIR Program), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), Israel Science Foundation, Swiss National Science Foundation, Austrian Science Fund (FWF), Swiss Cancer League, Agency for Science, Technology & Research (A*STAR) in Singapore, Singapore National Medical Research Council (Panel Member 2018-2020), Canadian Institutes of Health Research.

EDITORIAL BOARD

Science Immunology, Review Commons.

SELECTED INVITED LECTURES
2022
Gordon Research Conference on Immunochemistry and Immunobiology, Spain
2021
Argentinean Society of Immunology, Cordoba, Argentina
Immunology Seminar Series, Harvard Medical School, Boston, MA
Keystone Symposium on B cell-T cell collaboration, Alpbach, Austria
University of Fribourg, Switzerland (host: Jens Stein)
2020
TED Talk, Bocconi University, Milan, Italy
International HBV Meeting, Toronto, Canada (keynote lecture)
Louis Jeantet Symposium, Geneva, Switzerland
French Germinal Center Symposium, Paris (keynote lecture)
Ludwig-Maximilians University, Munich, Germany (PhD invited lecture)
Kantonsspital, St. Gallen, Switzerland (host: Burkhard Ludewig)
ANRS “Basic and Translation Research on Hepatitis Viruses”, Paris (keynote)
Keystone Symposium on Tissue Immunity, Boulder, CO
2019

Institut Curie, Paris, France (host: Nicolas Manel)

The Convergence of Hematology and Immunology (CHI), Tianjin, China

Armenise-Harvard Lecture, Harvard Medical School, Boston

Icahn School of Medicine at Mount Sinai, NYC (hosts: Brian Brown, Miriam Merad)

Tri-Institutional Seminar, New York City (hosts: Andrea Schietinger, Gabriel Victora)

International Congress of Immunology, Beijing

Peter Doherty Institute, Melbourne (host: Scott Mueller)

Joint German-Italian Immunological Society meeting, Munich

Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland

Young Scientist Forum, Prague, Czech Republic

Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute

TRON, Mainz, Germany (host: Ugur Sahin)

Tissue Immunity Symposium with a Focus on T cells, Lisbon, Portugal

CeMM, Vienna, Austria (host: Sylvia Knapp)

EASL International Liver Congress, Vienna, Austria

EMBO Gold Medalists Meeting, Singapore

Department of Pathology, UCSF (host: Max Krummel)

Gilead Sciences, Foster City, CA (host: Sarah Gilmore)

Stanford University, CA (host: Maria Grazia Roncarolo)

IRBM Science Park, Roma (host: Carlo Toniatti)

Harald von Boehmer Midwinter Conference, Seefeld, Austria

2018

Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)

Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada

World Congress on Microcirculation, Vancouver, Canada

5th European Congress of Immunology, Amsterdam

SIICA Advanced School in Immunology, Messina, Italy

European Institute of Oncology, Milan, Italy (host: Luigi Nezi)

Oxford University, UK (host: Jan Rehwinkel)

Cambridge University, UK (host: Milka Sarris)

44th Portuguese Society for Immunology Meeting, Lisbon, Portugal

Gordon Research Conference on Immunochemistry and Immunobiology, VT

Gordon Research Conference on Chemotactic Cytokines, Newry, ME

TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg

DKFZ, Heidelberg (host: Hellmut Augustin)

33rd Congress of the International Society for Advancement of Cytometry, Prague

The Crick Institute, London, UK (host: Caetano Reis e Sousa)

William Harvey Research Institute, London UK (host: Sussan Nourshargh)

University of Bern, Switzerland (host: Jens Stein)

University of Perugia, Italy (host: Francesca Fallarino)

Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany

27th Cytomeet (Keynote Lecture), Bern, Switzerland

Institute for Immunology, Munich, Germany (host: Thomas Brocker)

2017

ETH, Zurich, Switzerland (host: Annette Oxenius)

VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium (host: Max Mazzone)

deLIVER – Technology in Hepatology, Duesseldorf, Germany (keynote)

NIAID, NIH, Bethesda, MD (hosts: Ron Germain and Jon Yewdell)

Chiara D’Onofrio lecture at the SIBBM meeting, Milan, Italy

British Society of Immunology Leukocyte Migration Group, Leeds, UK

EMBO Symposium on Antigen Processing and Presentation, Salamanca, Spain

XI Meeting of the Italian Immunological Society (SIICA), Bari, Italy 

CRC/SFB 900 Symposium in Hannover, Germany

Centre d’Immunologie de Marseille-Luminy, France (host: Toby Lawrence)

Laboratory of Molecular and Cellular Biology, UCL, UK (host: Sophie Acton)

Gotheborg University, Sweden (host: Susanna Cardell)

2016

Perspective in Vascular Biology (SFB 834), Frankfurt, Germany

University of Bern, Switzerland (host: Jens Stein)

Gordon Research Conference “Immunochemistry and Immunobiology”, Il Ciocco

The Francis Crick Institute, London, UK (host: Caetano Reis e Sousa)

Symposium on Immunity and Inflammation, CNIC, Madrid, Spain

Pasteur Institute, Paris, France (host: Claude Leclerc)

8th International Singapore Symposium of Immunology, Singapore

Roche Glycart AG, Schlieren, Switzerland (host: Mario Perro)

TIGEM, Naples, Italy (host: Carmine Settembre)

University of Turin (host: Emilio Hirsch)

2016, Immunology Day, La Sapienza University, Rome, Italy

2015

GSK Vaccines, Siena, Italy (host: Ugo D’Oro)

Trafficking of immune cells in inflammation, development and disease (SFB 914)

Mainz, Germany (hosts: Ugur Sahin)

Karolinska Institute, Stockholm, Sweden (host: Eduardo Villablanca)

University of Oxford, UK (host: Oliver Bannard)

Cancer Research UK, London (host: Facundo Batista)

University College London, UK (host: Mala Maini)

Istituto Nazionale Genetica Molecolare, Milano, Italy (host: Jens Geginat)

University of Bern, Switzerland (host: Philippe Krebs)

1st European Chemokine and Cell Migration Conference, Villars-sur-Ollon, CH

European Society of Clinical Investigation Meeting, Cluj, Romania

EASL International Liver Congress, Vienna, Austria

University of Milan, Italy (host: Graziella Messina)

Annual Meeting of the Swiss Society for Allergology and Immunology, Basel

PATENTS
  • Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences

  • Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences

  • Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences

  • Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences

  • Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences

  • Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent Application 20130309270

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020016434

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781

  • De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (II), European Patent 19211249.8- 1110

  • Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Interleukin-2 gene therapy to restore antiviral T cell function in chronic HBV infection, UK Patent Application 1907493.9

CURRENT FUNDINGS

European Research Council - Consolidator Grant (725038)

FUNCIONAL BIOLOGY OF HEPATIC CD8+T CELLS

€ 2,390,000

July 2017 - June 2022

AIRC (Italian Association for Cancer Research) - Investigator Grant (19891)

SPATIOTEMPORAL DYNAMICS OF CD8+T CELLS WITHIN LIVER TUMORS

€ 1,062,000

January 2018 - December 2023

Italian Ministry of Health - Ricerca Finalizzata (RF-2018-12365801)

DETERMINANTS OF INTRAHEPATIC CD8+T CELL PRIMING

€ 450,000

November 2019 - November 2022

AIRC (Italian Association for Cancer Research) - 5 per 1000 (22737)

ADVANCED IMMUNE GENE AND CELL THERAPIES FOR LIVER METASTASES

€ 950,000

November 2019 - October 2026

Gilead Sciences

THE CAPACITY OF IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+T CELLS

€ 481,875

2019 - 2020