Matteo Iannacone.jpg

MATTEO IANNACONE

MD, PhD

Head, Dynamics of Immune Responses
Professor of Pathology
San Raffaele Scientific Institute & University

Via Olgettina 58 - 20132, Milan, Italy 

ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Researcher ID: I-8507-2018
Google Scholar
https://www.unisr.it/docenti/l/iannacone-matteo
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EDUCATION
 
2011

PhD

PhD IN IMMUNOLOGY

Vita-Salute San Raffaele University, Milan, Italy

2007

EUROPEAN BOARD CERTIFICATION IN INTERNAL MEDICINE 

2001

M.D.

M.D. DEGREE

University of Milan, Italy

positions and training
2015-present

Head

HEAD OF RESEARCH UNIT

San Raffaele Scientific Institute, Milan, Italy

2010-2015

Group Leader

GROUP LEADER

San Raffaele Scientific Institute, Milan, Italy

2007-2010

Postdoc

POSTDOCTORAL FELLOW

Harvard Medical School, Boston, MA

Advisor: Uli Von Andrian

2002-2006

Postdoc

POSTDOCTORAL FELLOW

The Scripps Research Institute, La Jolla, CA

Advisors: Luca Guidotti and Frank Chisari

HONORS AND AWARDS

Elected EMBO Member (2021)

Elected member of the Henry Kunkel Society (2020)

ERC panel member for Starting Grants LS6 "Immunity, Infection and Immunothepary" (2020)

Best 2019 Publication Award from the Italian Association for the Study of the Liver (AISF)

Chiara D'Onofrio Award (2017)

European Research Council (ERC) Consolidator Grant (2016)

EMBO Young Investigator Award (2016)

European Association for the Study of the Liver (EASL) Young Investigator Award (2015)

ERC Starting Grant (2011)

Armenise-Harvard Foundation Career Development Award (2010)

Armenise-Harvard Foundation Postdoctoral Fellowship (2008)

administrative and institutional responsabilities
2014-present

DIRECTOR OF INTRAVITAL IMAGING FACILITY

San Raffaele Scientific Institute, Milan, Italy

2014-present

IMMUNOLOGY SEMINAR SERIES ORGANIZING COMMITTEE

San Raffaele Scientific Institute, Milan, Italy

2015-present

EXTERNAL SEMINAR COMMITTEE

San Raffaele Scientific Institute, Milan, Italy

2020-present

COMMITTEE FOR APPOINTMENT AND PROMOTION

San Raffaele Scientific Institute, Milan, Italy

2017-2019

SCIENTIFIC BOARD

PhD program in Molecular Medicine, Vita-Salute San Raffaele University, Milan, Italy

PROFESSIONAL ACTIVITIES
JOURNAL REVIEWER

Nature, Science, Cell, Nature Medicine, Immunity, Nature Immunology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology.

SCIENTIFIC ADVISORY BOARD

Department of Immunology, Institut Pasteur (2019), Hepatitis B program, Gilead Sciences (2020 – present.

CONFERENCE ORGANIZATION

1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1stEMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rdInternational Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2020); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Milan, Italy (2021).

GRANT REVIEWER

European Research Council (ERC), UK Medical Research Council (MRC), European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM, Panel Member for the ATIP-AVENIR Program), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), Israel Science Foundation, Swiss National Science Foundation, Austrian Science Fund (FWF), Swiss Cancer League, Agency for Science, Technology & Research (A*STAR) in Singapore, Singapore National Medical Research Council (Panel Member 2018-2020), Canadian Institutes of Health Research.

EDITORIAL BOARD

Science Immunology, Review Commons.

SELECTED INVITED LECTURES
(last 5 years)
2022
FEBS-IUBMBM-ENABLE conference (The perfect tandem: how technology expands the frontiers of biomedicine), Sevilla, Spain (keynote)

Tissue inflammation, Hamburg, Germany

Immuneoctoberfest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany

1st Summer Symposium Systems Immunology “Network across scales”, Wurzburg, Germany 

9th ANRS HBV Cure Workshop, Lyon, France

Gordon Research Conference on Immunochemistry and Immunobiology, Spain

EMBL in Italy 2022: Emerging approaches in human health and infectious diseases, GSK Vaccines, Siena, Italy

XIII meeting of the Italian Society of Immunology (SIICA), Naples, Italy

Vir Biotechnology, Bellinzona, Switzerland (host: Davide Corti)

Ludwig Cancer Distinguished Seminar Series, Lausanne (host: Ping-Chih Ho)

Distinguished Seminar Series, The Jackson Laboratory for Genomic Medicine, Farmington, CT

Princeton University, USA (host: Alex Ploss)

Portuguese Society of Immunology (SPI) annual meeting, Lisbon, Portugal

King’s College, London, UK (host: Alberto Sanchez-Fueyo)

Scottish Immunology Groups Network, Perth, Scotland (keynote lecture)

European School of Molecular Medicine, Milan, Italy

2021

University of Salzburg, Austria (host: Iris Gratz)

Argentinean Society of Immunology, Cordoba, Argentina (keynote lecture)

University of Milan, Italy (PhD invited lecture)

University of Massachusetts Medical School (host: Andrea Reboldi)

International HBV Meeting, Toronto, Canada (keynote lecture)

Austrian Association of the Molecular Life Sciences and Biotechnology annual meeting, Innsbruck, Tyrol, Austria 

5th Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), Cagliari, Italy

Swiss Society for Allergology and Immunology, Zurich, Switzerland 

French Germinal Center Symposium, Paris (keynote lecture)

Oxford Imaging Symposium, UK (host: Michael Dustin)

Immunology Seminar Series, Harvard Medical School, Boston, MA

Global Immunotalk (hosts: Carla Rothlin and Elina Zuniga)

University of Fribourg, Switzerland (host: Jens Stein)

T cell connect Europe, Immunology lecture series

2020
Ludwig-Maximilians University, Munich, Germany (PhD invited lecture)

Kantonsspital, St. Gallen, Switzerland (host: Burkhard Ludewig)

Louis Jeantet Symposium, Geneva, Switzerland 

Cambridge Immunology Network, UK (host: Menna Clatworthy)

Advanced School of Immunology, Italian Association of Immunologists (SIICA)

ANRS “Basic and Translation Research on Hepatitis Viruses”, Paris (keynote)

Keystone Symposium on Tissue Immunity, Boulder, CO

2019

Institut Curie, Paris, France (host: Nicolas Manel)

The Convergence of Hematology and Immunology (CHI), Tianjin, China

Armenise-Harvard Lecture, Harvard Medical School, Boston

Icahn School of Medicine at Mount Sinai, NYC (hosts: Brian Brown, Miriam Merad)

Tri-Institutional Seminar, New York City (hosts: Andrea Schietinger, Gabriel Victora)

International Congress of Immunology, Beijing

Peter Doherty Institute, Melbourne (host: Scott Mueller)

Joint German-Italian Immunological Society meeting, Munich

Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland

Young Scientist Forum, Prague, Czech Republic

Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute

TRON, Mainz, Germany (host: Ugur Sahin)

Tissue Immunity Symposium with a Focus on T cells, Lisbon, Portugal

CeMM, Vienna, Austria (host: Sylvia Knapp)

EASL International Liver Congress, Vienna, Austria

EMBO Gold Medalists Meeting, Singapore

Department of Pathology, UCSF (host: Max Krummel)

Gilead Sciences, Foster City, CA (host: Sarah Gilmore)

Stanford University, CA (host: Maria Grazia Roncarolo)

IRBM Science Park, Roma (host: Carlo Toniatti)

Harald von Boehmer Midwinter Conference, Seefeld, Austria

2018

Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)

Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada

World Congress on Microcirculation, Vancouver, Canada

5th European Congress of Immunology, Amsterdam

SIICA Advanced School in Immunology, Messina, Italy

European Institute of Oncology, Milan, Italy (host: Luigi Nezi)

Oxford University, UK (host: Jan Rehwinkel)

Cambridge University, UK (host: Milka Sarris)

44th Portuguese Society for Immunology Meeting, Lisbon, Portugal

Gordon Research Conference on Immunochemistry and Immunobiology, VT

Gordon Research Conference on Chemotactic Cytokines, Newry, ME

TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg

DKFZ, Heidelberg (host: Hellmut Augustin)

33rd Congress of the International Society for Advancement of Cytometry, Prague

The Crick Institute, London, UK (host: Caetano Reis e Sousa)

William Harvey Research Institute, London UK (host: Sussan Nourshargh)

University of Bern, Switzerland (host: Jens Stein)

University of Perugia, Italy (host: Francesca Fallarino)

Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany

27th Cytomeet (Keynote Lecture), Bern, Switzerland

Institute for Immunology, Munich, Germany (host: Thomas Brocker)

PATENTS
  • Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences

  • Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences

  • Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences

  • Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences

  • Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences

  • Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent Application 20130309270

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020016434

  • Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781

  • De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (II), European Patent 19211249.8- 1110

  • Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Interleukin-2 gene therapy to restore antiviral T cell function in chronic HBV infection, UK Patent Application 1907493.9

CURRENT FUNDINGS

European Research Council - Consolidator Grant (725038)

FUNCIONAL BIOLOGY OF HEPATIC CD8+T CELLS

€ 2,390,000

July 2017 - June 2022

European Research Council - Proof of Concept Grand (957502)

IL-2 GENE THERAPY FOR CHRONIC HEPATITIS B VIRUS INFECTION

€ 150,000

July 2020 - June 2022

AIRC (Italian Association for Cancer Research) - Investigator Grant (19891)

SPATIOTEMPORAL DYNAMICS OF CD8+T CELLS WITHIN LIVER TUMORS

€ 1,062,000

January 2018 - December 2023

Italian Ministry of Health - Ricerca Finalizzata (RF-2018-12365801)

DETERMINANTS OF INTRAHEPATIC CD8+T CELL PRIMING

€ 450,000

November 2019 - November 2022

AIRC (Italian Association for Cancer Research) - 5 per 1000 (22737)

ADVANCED IMMUNE GENE AND CELL THERAPIES FOR LIVER METASTASES

€ 950,000

November 2019 - October 2026

Gilead Sciences

THE CAPACITY OF IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+T CELLS

€ 481,875

2019 - 2020

Asher Bio

TO DETERMINE THE CAPACITY OF CD8-TARGETED IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+T CELLS

€ 266,500

2021 - 2022

Takis Biotech

THE CAPACITY OF VACCINES AND SINGLE-CHAIN ANTIBODIES TO PREVENT SARS-COV-2 INFECTION

€ 135,000

2021 - 2022

Vir Biotechnology

TO CHARACTERIZE THE IN VIVO EFFECT OF HUMAN MONOCLONAL ANTIBODIES AGAINST HBV

€ 67,500

2021 - 2022