MATTEO IANNACONE
MD, PhD
Head, Dynamics of Immune Responses
Professor of Pathology
San Raffaele Scientific Institute & University
Via Olgettina 58 - 20132, Milan, Italy
ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Researcher ID: I-8507-2018
Google Scholar
https://www.unisr.it/docenti/l/iannacone-matteo
EDUCATION
2011
PhD
PhD IN IMMUNOLOGY
Vita-Salute San Raffaele University, Milan, Italy
2007
EUROPEAN BOARD CERTIFICATION IN INTERNAL MEDICINE
2001
M.D.
M.D. DEGREE
University of Milan, Italy
positions and training
2015-present
Head
HEAD OF RESEARCH UNIT
San Raffaele Scientific Institute, Milan, Italy
2010-2015
Group Leader
GROUP LEADER
San Raffaele Scientific Institute, Milan, Italy
2007-2010
Postdoc
POSTDOCTORAL FELLOW
Harvard Medical School, Boston, MA
Advisor: Uli Von Andrian
2002-2006
Postdoc
POSTDOCTORAL FELLOW
The Scripps Research Institute, La Jolla, CA
Advisors: Luca Guidotti and Frank Chisari
HONORS AND AWARDS
Elected EMBO Member (2021)
Elected member of the Henry Kunkel Society (2020)
ERC panel member for Starting Grants LS6 "Immunity, Infection and Immunothepary" (2020)
Best 2019 Publication Award from the Italian Association for the Study of the Liver (AISF)
Chiara D'Onofrio Award (2017)
European Research Council (ERC) Consolidator Grant (2016)
EMBO Young Investigator Award (2016)
European Association for the Study of the Liver (EASL) Young Investigator Award (2015)
ERC Starting Grant (2011)
Armenise-Harvard Foundation Career Development Award (2010)
Armenise-Harvard Foundation Postdoctoral Fellowship (2008)
administrative and institutional responsabilities
2014-present
DIRECTOR OF INTRAVITAL IMAGING FACILITY
San Raffaele Scientific Institute, Milan, Italy
2014-present
IMMUNOLOGY SEMINAR SERIES ORGANIZING COMMITTEE
San Raffaele Scientific Institute, Milan, Italy
2015-present
EXTERNAL SEMINAR COMMITTEE
San Raffaele Scientific Institute, Milan, Italy
2020-present
COMMITTEE FOR APPOINTMENT AND PROMOTION
San Raffaele Scientific Institute, Milan, Italy
2017-2019
SCIENTIFIC BOARD
PhD program in Molecular Medicine, Vita-Salute San Raffaele University, Milan, Italy
PROFESSIONAL ACTIVITIES
JOURNAL REVIEWER
Nature, Science, Cell, Nature Medicine, Immunity, Nature Immunology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology.
SCIENTIFIC ADVISORY BOARD
Department of Immunology, Institut Pasteur (2019), Hepatitis B program, Gilead Sciences (2020 – present.
CONFERENCE ORGANIZATION
1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1stEMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rdInternational Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2020); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Milan, Italy (2021).
GRANT REVIEWER
European Research Council (ERC), UK Medical Research Council (MRC), European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM, Panel Member for the ATIP-AVENIR Program), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), Israel Science Foundation, Swiss National Science Foundation, Austrian Science Fund (FWF), Swiss Cancer League, Agency for Science, Technology & Research (A*STAR) in Singapore, Singapore National Medical Research Council (Panel Member 2018-2020), Canadian Institutes of Health Research.
EDITORIAL BOARD
Science Immunology, Review Commons.
SELECTED INVITED LECTURES
2022
FEBS-IUBMBM-ENABLE conference (The perfect tandem: how technology expands the frontiers of biomedicine), Sevilla, Spain (keynote)
Tissue inflammation, Hamburg, Germany
Immuneoctoberfest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
1st Summer Symposium Systems Immunology “Network across scales”, Wurzburg, Germany
9th ANRS HBV Cure Workshop, Lyon, France
Gordon Research Conference on Immunochemistry and Immunobiology, Spain
EMBL in Italy 2022: Emerging approaches in human health and infectious diseases, GSK Vaccines, Siena, Italy
XIII meeting of the Italian Society of Immunology (SIICA), Naples, Italy
Vir Biotechnology, Bellinzona, Switzerland (host: Davide Corti)
Ludwig Cancer Distinguished Seminar Series, Lausanne (host: Ping-Chih Ho)
Distinguished Seminar Series, The Jackson Laboratory for Genomic Medicine, Farmington, CT
Princeton University, USA (host: Alex Ploss)
Portuguese Society of Immunology (SPI) annual meeting, Lisbon, Portugal
King’s College, London, UK (host: Alberto Sanchez-Fueyo)
Scottish Immunology Groups Network, Perth, Scotland (keynote lecture)
European School of Molecular Medicine, Milan, Italy
2021
University of Salzburg, Austria (host: Iris Gratz)
Argentinean Society of Immunology, Cordoba, Argentina (keynote lecture)
University of Milan, Italy (PhD invited lecture)
University of Massachusetts Medical School (host: Andrea Reboldi)
International HBV Meeting, Toronto, Canada (keynote lecture)
Austrian Association of the Molecular Life Sciences and Biotechnology annual meeting, Innsbruck, Tyrol, Austria
5th Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), Cagliari, Italy
Swiss Society for Allergology and Immunology, Zurich, Switzerland
French Germinal Center Symposium, Paris (keynote lecture)
Oxford Imaging Symposium, UK (host: Michael Dustin)
Immunology Seminar Series, Harvard Medical School, Boston, MA
Global Immunotalk (hosts: Carla Rothlin and Elina Zuniga)
University of Fribourg, Switzerland (host: Jens Stein)
T cell connect Europe, Immunology lecture series
2020
Ludwig-Maximilians University, Munich, Germany (PhD invited lecture)
Kantonsspital, St. Gallen, Switzerland (host: Burkhard Ludewig)
Louis Jeantet Symposium, Geneva, Switzerland
Cambridge Immunology Network, UK (host: Menna Clatworthy)
Advanced School of Immunology, Italian Association of Immunologists (SIICA)
ANRS “Basic and Translation Research on Hepatitis Viruses”, Paris (keynote)
Keystone Symposium on Tissue Immunity, Boulder, CO
2019
Institut Curie, Paris, France (host: Nicolas Manel)
The Convergence of Hematology and Immunology (CHI), Tianjin, China
Armenise-Harvard Lecture, Harvard Medical School, Boston
Icahn School of Medicine at Mount Sinai, NYC (hosts: Brian Brown, Miriam Merad)
Tri-Institutional Seminar, New York City (hosts: Andrea Schietinger, Gabriel Victora)
International Congress of Immunology, Beijing
Peter Doherty Institute, Melbourne (host: Scott Mueller)
Joint German-Italian Immunological Society meeting, Munich
Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland
Young Scientist Forum, Prague, Czech Republic
Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute
TRON, Mainz, Germany (host: Ugur Sahin)
Tissue Immunity Symposium with a Focus on T cells, Lisbon, Portugal
CeMM, Vienna, Austria (host: Sylvia Knapp)
EASL International Liver Congress, Vienna, Austria
EMBO Gold Medalists Meeting, Singapore
Department of Pathology, UCSF (host: Max Krummel)
Gilead Sciences, Foster City, CA (host: Sarah Gilmore)
Stanford University, CA (host: Maria Grazia Roncarolo)
IRBM Science Park, Roma (host: Carlo Toniatti)
Harald von Boehmer Midwinter Conference, Seefeld, Austria
2018
Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)
Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada
World Congress on Microcirculation, Vancouver, Canada
5th European Congress of Immunology, Amsterdam
SIICA Advanced School in Immunology, Messina, Italy
European Institute of Oncology, Milan, Italy (host: Luigi Nezi)
Oxford University, UK (host: Jan Rehwinkel)
Cambridge University, UK (host: Milka Sarris)
44th Portuguese Society for Immunology Meeting, Lisbon, Portugal
Gordon Research Conference on Immunochemistry and Immunobiology, VT
Gordon Research Conference on Chemotactic Cytokines, Newry, ME
TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg
DKFZ, Heidelberg (host: Hellmut Augustin)
33rd Congress of the International Society for Advancement of Cytometry, Prague
The Crick Institute, London, UK (host: Caetano Reis e Sousa)
William Harvey Research Institute, London UK (host: Sussan Nourshargh)
University of Bern, Switzerland (host: Jens Stein)
University of Perugia, Italy (host: Francesca Fallarino)
Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany
27th Cytomeet (Keynote Lecture), Bern, Switzerland
Institute for Immunology, Munich, Germany (host: Thomas Brocker)
PATENTS
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Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences
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Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences
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Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences
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Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences
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Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences
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Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent Application 20130309270
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Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427
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Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020016434
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Summa V, Di Fabio R, Bencheva L, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781
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De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (II), European Patent 19211249.8- 1110
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Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Interleukin-2 gene therapy to restore antiviral T cell function in chronic HBV infection, UK Patent Application 1907493.9
CURRENT FUNDINGS
European Research Council - Consolidator Grant (725038)
FUNCIONAL BIOLOGY OF HEPATIC CD8+T CELLS
€ 2,390,000
July 2017 - June 2022
European Research Council - Proof of Concept Grand (957502)
IL-2 GENE THERAPY FOR CHRONIC HEPATITIS B VIRUS INFECTION
€ 150,000
July 2020 - June 2022
AIRC (Italian Association for Cancer Research) - Investigator Grant (19891)
SPATIOTEMPORAL DYNAMICS OF CD8+T CELLS WITHIN LIVER TUMORS
€ 1,062,000
January 2018 - December 2023
Italian Ministry of Health - Ricerca Finalizzata (RF-2018-12365801)
DETERMINANTS OF INTRAHEPATIC CD8+T CELL PRIMING
€ 450,000
November 2019 - November 2022
AIRC (Italian Association for Cancer Research) - 5 per 1000 (22737)
ADVANCED IMMUNE GENE AND CELL THERAPIES FOR LIVER METASTASES
€ 950,000
November 2019 - October 2026
Gilead Sciences
THE CAPACITY OF IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+T CELLS
€ 481,875
2019 - 2020
Asher Bio
TO DETERMINE THE CAPACITY OF CD8-TARGETED IL-2 MOLECULES TO INCREASE THE NUMBER AND/OR FUNCTION OF INTRAHEPATICALLY PRIMED HBV-SPECIFIC CD8+T CELLS
€ 266,500
2021 - 2022
Takis Biotech
THE CAPACITY OF VACCINES AND SINGLE-CHAIN ANTIBODIES TO PREVENT SARS-COV-2 INFECTION
€ 135,000
2021 - 2022
Vir Biotechnology
TO CHARACTERIZE THE IN VIVO EFFECT OF HUMAN MONOCLONAL ANTIBODIES AGAINST HBV
€ 67,500
2021 - 2022