top of page

2024

 

Nature Immunology Mar 24.png

August 2024

The hidden strength of CD8+ T cells in chronic hepatitis B

Andreata F, Iannacone M

 

Journal of Hepatology Nov 22.gif

July 2024

Intrahepatic immunity to hepatitis B virus

Venzin V, Beccaria CG, Andreata F, Fumagalli V, Iannacone M

 

Cell July 24.jpg

July 2024

Therapeutic potential of co-signaling receptor modulation in hepatitis B

Andreata F, Krueger CC, Laura C, Ravà M, Ficht X, Kawashima K, Beccaria CG, Moalli F, Partini B, Fumagalli V, Nosetto G, Di Lucia P, Montali I, Garcia-Manteiga JM, Bono EB, Giustini L, Perucchini C, Venzin V, Ranucci S, Inverso D, De Giovanni M, Genua M, Ostuni R, Lugli E, Isogawa M, Ferrari C, Boni C, Fisicaro P, Guidotti LG, Iannacone M

 

Nature Immunology Mar 24.png

March 2024

Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination

Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M

 

Science Jan 24.jpg

January 2024

Deterministic reprogramming of neutrophils within tumors

Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jing J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Moalli F, Liu Z, Duan K, Narang V, Ballesteros I, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y-H, Tey HL, Chong SH, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG

 

Nature Communications Mar 23.jpg

August 2024

LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness

Pallavicini I, Frasconi T, Catozzi C, Tiberti S, Ceccaci E, Hass D, Samson J, Heuser C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T

 

10.png

July 2024

Advancements in Pathogen Immunity and Signaling

Gyrd-Hansen M, Kajaste-Rudnitski A, Manel N, Rehwinkel J, van der Veen AG, Iannacone M

 

Journal of General Virology may 24.jpg

May 2024

Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus

HBV2023, Allweiss L, Cohen C, Dias J, Fumagalli V, Guo H, Harris JM, Hu J, Iannacone M, Isogawa M, Jeng W-J, Kim K-H, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh S-H, McKeating JA, Revill PA

 

Cellular and molecolar immunology Nov 23.png

February 2024

The interplay of drug therapeutics and immune responses to SARS-CoV-2

Fumagalli V, Iannacone M

 

Science Translational Medicine Jan 24.jpg

January 2024

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus

Andreata F, Moynihan KD, Fumagalli V, Di Lucia P, Pappas DC, Kawashima K, Ni I, Bessette PH, Perucchini C, Bono E, Giustini L, Nguyen HC, Chin SM, Yeung YA, Gibbs CS, Djuretic I, Iannacone M

 

JCI 24.jpg

August 2024

Gpr126 is a crucial regulator of blood-brain barrier maturation and function

Kakogiannos N, Scalise AA, Martini E, Maderna C, Benvenuto AF, D’Antonio M, Carmignani L, Magni S, Gullotta GS, Lampugnani MG, Iannelli F, Beznoussenko GV, Mironov AA, Cerutti C, Bentley K, Philippides A, Zanardi F, Bacigaluppi M, Sigismund S, Bassani C, Farina C, Martino G, Dejana E, Iannacone M#, Inverso D#, Giannotta M#

 

Schermata 2020-04-02 alle 16.47.15.png

June 2024

Plasmacytoid dendritic cells regulate tissue homeostasis of megakaryocytes

Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Guo G, Belz L, Sobirova G, Zhang Z, Titova A, Martinez Navarro A, Pekayvaz K, Lorenz M, von Baumgarten L, Straub T, Popper B, Zheden V, Kaufmann W, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Broker T, Walzog B, Scheiermann C, Aird W,Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendrop RAJ, Iannacone M, Heinig M, Massberg S

 

JHEP Reports May 24.gif

May 2024

Preclinical evaluation of therapeutic peptide-glycolipid conjugate vaccines for chronic hepatitis B virus that stimulate antiviral activities of T cells and NKT cells

Mooney AH, Draper SL, Burn OK, Andreson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab S, Painter GF, Hermans IF

 

Annual Review of Immunology Feb 24.png

February 2024

Priming and maintenance of adaptive immunity in the liver

Kawashima K, Andreata F, Beccaria CG, Iannacone M

 

2023

 

signaling dec 2023.jpg

December 2023

The lysine demethylase LSD1 controls the balance between inflammatory and antivral responses against coronaviruses

Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilan E, Romanenghi M, Achutti Duso B, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, De Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG

 

Vaccines sept 2023.png

September 2023

Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine

Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Coria L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G

 

Nature Cell Biology Apr 23.png

April 2023

SARS-CoV-2 infection causes DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence

Gioia U, Tavella S, Martinez Orellana P, Cicio G, Colliva A, Paldino A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paladino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d’Adda di Fagagna F

 

Nature Immunology Feb 23.png

February 2023

Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development

Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D

 

Immunity dec 2023.gif

December 2023

Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis

Haberman ER, Sarker G, Arus BA, Ziegler KA, Meunier S, Martinez-Sanchez N, Freibergerova E, Yilmaz-Özcan S, Fernandez-Gonzalez I, Zentai C, O’Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, Lopez M, Ginhoux F, Domingos AI

 

European Journal of Immunology Sep 23.jpg

September 2023

A fluorescent reporter model for the visualization and characterization of TDC

Fiore A, Sala E, Laura C, Riba M, Fumagalli V, Nelli M, Mangione M, Provero P, Oberrauch F, Cristofani C, Iannacone M, Kuka M

 

EMBO Molecular Medicine Mar 23.jpg

March 2023

Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts antiviral adaptive immune responses

Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M

 

Nature nov 2023.png

November 2023

IL-1b+ macrophages fuel pathogenic inflammation in pancreatic cancer

Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro E, Ng MSF, Lena MS, Drago D, Andolfo A, Mortellaro A, Corbo V, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R

 

Journal of Experimental Medicine Sep 23.png

September 2023

The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling

Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N

 

Nature Communications Mar 23.jpg

March 2023

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Stoler-Barak L, Harris E, Peres A, Hezroni H, Kuka M, Di Lucia P, Grenov A, Gurwicz N, Kupervaser M, Yip BH, Iannacone M, Yaari G, Crispino JD, Shulman Z

 

2022

 

Pharmacological Research Dec 22.gif

December 2022

Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19

Epis S, Varotto-Boccazzi I, Manenti A, Rubolini D, Gabrieli P, Cattaneo GM, Gourlay L, Dapporto F, Monti M, Razzano I, Leonardi M, Iannacone M, Recordati C, Bertola L, Fiorina P, Marvasi L, Montomoli E, Zuccotti GV, Bandi C

Vaccines July 22.PNG

July 2022

DNA-vaccine-induced immune response correlates with lower viral SARS-CoV-2 titers in a ferret model

Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Ravà M, Ryan K, Hall Y, Rayner E, Salguero J, Paterson J, Iannacone M, De Francesco R, Aurisicchio L*, Palombo F*

sciimmunol.2022.7.issue-72.largecover.jpg

June 2022

Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype

Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Müller C*, Stein JV*

 

d41586-022-00813-0_20253740.jpeg

March 2022

Developing a cure for chronic hepatitis B requires a fresh approach. 

Matteo Iannacone and Luca Guidotti

 

sciimmunol.2022.7.issue-68.largecover.jpg

February 2022

Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability

Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M

 

Nature_Communications_-_Journal_Cover.jpeg

February 2022

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Pekayvaz K, Leunig A, Kaiser R, Brambs S, Joppich M, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wiser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hölscher M, Massberg S, Stark K, Nicolai L 

 

1-s2.0-S1525001621X00056-cov200h (1).gif

January 2022

COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models

Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M#, Aurisicchio L#

 

Journal of Hepatology Nov 22.gif

November 2022

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as potential therapeutic target

Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, Tufano M, Peano C, Iannacone M, Roychoudhuri R, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A

Immunity Jul 22.jpg

July 2022

Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells

Iannacone M, Bleriot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F

 

1-s2.0-S0952791522X00046-cov200h.gif

August 2022

Immunological insights in the treatment of chronic hepatitis B 

Iannacone M, Andreata F, Guidotti LG

 

X01652478.jpg

May 2022

Heterogeneity of tissue resident memory T cells

Konjar Š*, Ficht X*, Iannacone M#, Veldhoen M#

 

sciimmunol.2022.7.issue-67.largecover.jpg

January 2022

Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M

 

signaling.2022.15.issue-743.cover.jpg

February 2022

Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets

Aiolfi R*, Sitia G*, Iannacone M*, Brunetta I, Guidotti LG, Ruggeri ZM

 

Bioorganic & Medicinal Chemistry Letters Oct 22.gif

October 2022

​Discovery and antiviral profile of new sulfamoylbenzamide derivative as HBV capsid assembly modulators

Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Orsale MV, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R

Viral pathogenesis. Current Opinion in Virology July 22.jpg

July 2022

Editorial overview: Viral pathogenesis

Bertoletti A, Iannacone M

 

m_bloodjournal_139_17.cover.png

April 2022

Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration

Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht M-L, Zhang Z, Kugelmann, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S

 

3.png

March 2022

The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response

Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria C, David E, Maier B, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A#, Merad M#, Amit I#

 

imr.v306.1.cover.jpg

March 2022

Heterogeneity in antiviral B cell responses: Lessons from the movies

Mirela Kuka, Iannacone M

 

1.png

January 2022

Immunobiology and pathogenesis of hepatitis B virus infection

Matteo Iannacone and Luca Guidotti

 

2021

 

eji.webp

December 2021

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Cossarizza A, Chang HD, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria CG... Iannacone M, ..., Yang J 

 

1-s2.0-S2666166720X00086-cov200h.gif

December 2021

Isolation of mouse Kupffer cells for phenotypic and functional studies. 

Andreata F, De Simone G, Fumagalli V, Di Lucia P, Ficht X, Beccaria CG, Bleriot C, Kuka M, Ginhoux F, Iannacone M.

 

1-s2.0-S1074761320X00094-cov200h.gif

August 2021

A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression.

Cilenti F, Barbiera G, Caronni N, Iodice D, Barresi S, Montaldo E, Lusito E, Miotto P, Di Lucia P, Lazarevic D, Cirillo D, Iannacone M, Genua M*, Ostuni R*

 

10.png

October 2021

Repositioning Th cell polarization from single cytokines to complex help.

Tuzlak S, Dejean A, Iannacone M, Quintana F, Waisman A, Ginhoux F, Korn T, Becher B

 

1-s2.0-S1074761320X00100-cov200h.gif

September 2021

Identification of two subsets of Kupffer cells with distinct functions in liver metabolism.

Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang X-M, Ang N, Shen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell E, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F.

 

plos.png

May 2021

IFN signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen.

Baudi I, Isogawa M, Moalli F, Onishi M, Kawashima K, Ito H, Ishikawa T, Wakita T, Iannacone M, Tanaka Y

 

cti2.v10.9.cover.jpg

September 2021

miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance.

Fedeli M, Kuka M, Finardi A, Albano F, Viganò V, Olson EN, Iannacone M, Furlan R, Dellabona P*, Casorati G*

 

1-s2.0-S1074761320X00100-cov200h.gif

September 2021

Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming.

De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M

 

2020

 

kvir20.v011.i01.jpg

November 2020

Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection.

Perro M, Iannacone M, von Andrian UH, Peixoto A.

 

sciimmunol.2020.5.issue-46.largecover.jpg

April 2020

Salivary gland macrophages and tissue-resident CD8+T cells cooperate for homeostatic organ surveillance.

Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV.

 

sciimmunol.2020.5.issue-51.largecover.jpg

September 2020

Immune surveillance of the liver by T cells.

Xenia Ficht and Matteo Iannacone.

 

3.png

March 2020

Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization.

De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M, Iannacone M.

 

m_jem_217_11.cover.png

August 2020

Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.

Valeria Fumagalli, Pietro Di Lucia, Valentina Venzin, Elisa B. Bono1, Robert Jordan, Christian R. Frey, William Delaney, Francis V. Chisari, Luca G. Guidotti*, and Matteo Iannacone*.

 

2020
2021
2022
2023
2024
2019
Schermata 2020-04-02 alle 16.44.33.png

November 2019

CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential.

De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E 

F1.medium.gif

May 2019

Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates.

De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E 

X01652478.jpg

November 2019

The role of type I interferons in CD4+ T cell differentiation.

Kuka M, De Giovanni M, Iannacone M

Schermata 2020-04-02 alle 16.47.15.png

October 2019

Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.

Benechet AP*, De Simone G*, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M

2019

 

2018

2018

 

m_jem_215_12_cover.png

November 2018

The conduit system exports locally secreted IgM from lymph nodes.

DeThierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M*, Bajenoff M*

Schermata 2020-04-02 alle 19.03.00.png

July 2018

Zika virus replication in dorsal root ganglia explants causes myelin degeneration. 

Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E

4.png

April 2018

Viral subversion of B cell responses within secondary lymphoid organs.

Kuka M, Iannacone M

3-18-cover.jpg

September 2018

Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity.

Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E 

eji201870100-gra-0001-m.jpg

August 2018

Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection. 

Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G 

978-1-4939-7762-8.jpeg

April 2018

Intravital imaging of B cell responses in lymph nodes

Sammicheli S, Kuka M, Iannacone M

m_jem_215_6_cover.png

June 2018

The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ cells

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV  

frontiers-in-immunology_300x388px-96dpi-

April 2018

Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node 

Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli 

1-s2.0-S1879625717X00072-cov150h.gif

February 2018

In vivo imagina of adaptive immune responses to viruses. 

De Giovanni M and Iannacone M

2017

2017

 

F1.medium.gif

December 2017

Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq.

DeMedaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M, Shulman Z, Amit I

11.png

November 2017

Sympathetic associated macrophages clear norepinephrine and sustain obesity.

Pirzgalska RM*, Seixas E*, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI

frontiers-in-immunology_300x388px-96dpi-

July 2017

Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives viral persistence.

Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G

frontiers-in-immunology_300x388px-96dpi-

May 2017

In vivo chronic stimulation unveils intrinsic auto reactive potential of Wiskott-Aldrich syndrome protein-deficient B cells.

Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M

cover.tif-5.jpg

January 2017

Determinants of hepatic effector CD8+ T cell dynamics.

Benechet AP, Iannacone M

cover.tif.jpg

November 2017

Migrating platelets are Mechano-scavengers that collect and bundle bacteria.

Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S

emmm.v9.11.cover.jpg

November 2017

Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens.

Jimenez de Oya N*, De Giovanni M*, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M

F1.medium-2.gif

July 2017

Constitutive resistance to viral infection in human CD141+ dendritic cells.

Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N

cover.tif-4.jpg

February 2017

CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperatively to optimize priming.

Brewitz A, Eickhoff S, Dahling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmuller W

cover.tif-2.jpg

November 2017

Intestinal flossing keeps pathogens at bay.

Kuka M and Iannacone M

X00219290.jpg

October 2017

Microcirculation in mouse live lobule: a computational fluir dynamic model based on 3D reconstruction from in vivo microscopy.

Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G

cover.tif-3.jpg

September 2017

Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology.

Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M

7651.png

January 2017

Intravital microscopy analysis of hepatic T cell dynamics.

Benechet AP, Ganzer K, Iannacone M

2016

2016

 

X10445323.jpg

May 2016

Platelet-mediated modulation of adaptive immunity.

Iannacone M

emmm.v8.2.cover.jpg

January 2016

IFNa gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.

Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G

F1.medium-3.gif

October 2016

Inflammatory monocytes hinder antiviral B cell responses.

Sammicheli S*, Kuka M*, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, De La Torre JC, Guidotti LG, Iannacone M

jlb.99.1.i.fp.png

January 2016

Spatiotemporal dynamics of effector CD8+ T cell responses within the liver.

Inverso D, Iannacone M

9780123742797.jpg

September 2016

Protective and pathogenic T cell responses to virus infections.

Iannacone M, Chisari FV, Guidotti LG

2015

2015

 

cover.tif-6.jpg

April 2015

Immunosurveillance of the liver by intravascular effector CD8+ T cells.

Guidotti LG*, Inverso D*, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez- Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M

inocaj.2015.54.issue-2.largecover.jpg

January 2015

A luminescent poly(amidoamine)-iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy.

Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G

F1.medium-4.gif

November 2015

Mouse models of HBV pathogenesis.

Iannacone M, Guidotti LG

4-2.png

May 2015

Hepatic effector CD8+ T cell dynamics.

Iannacone M

1-s2.0-S1879625714X00052-cov150h.gif

November 2015

Viral pathogenesis.

Iannacone M, Guidotti LG

2014

2014

 

X15216616.jpg

April 2014

PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.

Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M

nyas.2014.1319.issue-1.cover.jpg

June 2014

The role of lymph node sinus macrophages in host defense.

Kuka M, Iannacone M

nature_scientific_reports.png

December 2014

In vivo flow mapping in complex vessel networks by single image correlation

Sironi L, Bouzin M, Inverso D, D'Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G

X0264410X.jpg

May 2014

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.

Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Jhonston LP, Kishimoto TK

2013
cover.tif-7.jpg

October 2013

Biophosphonates target B cells to enhance humoral immune responses.

Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M

01615890.jpg

August 2013

Effector CD8 T cell trafficking within the liver

Guidotti LG, Iannacone M

cover.tif-8.jpg

September 2013

Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions.

Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, Von Andrian UH

cover.tif-9.jpg

November 2013

Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.

Sitia G, Iannacone M, Guidotti LG

2013

 

2012

2012

 

cov200h-2.gif

September 2012

Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes.

Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, Von Andrian UH

Schermata 2020-04-30 alle 13.23.40.png

April 2012

Follicular helper NKT cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+T cells.

Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, 

32.cover-source.jpg

August 2012

Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.

Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG

cover.tif-10.jpg

March 2012

B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.

Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH

bottom of page