2024
August 2024
The hidden strength of CD8+ T cells in chronic hepatitis B
Andreata F, Iannacone M
July 2024
Intrahepatic immunity to hepatitis B virus
Venzin V, Beccaria CG, Andreata F, Fumagalli V, Iannacone M
July 2024
Therapeutic potential of co-signaling receptor modulation in hepatitis B
Andreata F, Krueger CC, Laura C, Ravà M, Ficht X, Kawashima K, Beccaria CG, Moalli F, Partini B, Fumagalli V, Nosetto G, Di Lucia P, Montali I, Garcia-Manteiga JM, Bono EB, Giustini L, Perucchini C, Venzin V, Ranucci S, Inverso D, De Giovanni M, Genua M, Ostuni R, Lugli E, Isogawa M, Ferrari C, Boni C, Fisicaro P, Guidotti LG, Iannacone M
March 2024
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M
January 2024
Deterministic reprogramming of neutrophils within tumors
Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jing J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Moalli F, Liu Z, Duan K, Narang V, Ballesteros I, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y-H, Tey HL, Chong SH, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG
August 2024
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness
Pallavicini I, Frasconi T, Catozzi C, Tiberti S, Ceccaci E, Hass D, Samson J, Heuser C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T
July 2024
Advancements in Pathogen Immunity and Signaling
Gyrd-Hansen M, Kajaste-Rudnitski A, Manel N, Rehwinkel J, van der Veen AG, Iannacone M
May 2024
Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus
HBV2023, Allweiss L, Cohen C, Dias J, Fumagalli V, Guo H, Harris JM, Hu J, Iannacone M, Isogawa M, Jeng W-J, Kim K-H, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh S-H, McKeating JA, Revill PA
February 2024
The interplay of drug therapeutics and immune responses to SARS-CoV-2
Fumagalli V, Iannacone M
January 2024
CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus
Andreata F, Moynihan KD, Fumagalli V, Di Lucia P, Pappas DC, Kawashima K, Ni I, Bessette PH, Perucchini C, Bono E, Giustini L, Nguyen HC, Chin SM, Yeung YA, Gibbs CS, Djuretic I, Iannacone M
August 2024
Gpr126 is a crucial regulator of blood-brain barrier maturation and function
Kakogiannos N, Scalise AA, Martini E, Maderna C, Benvenuto AF, D’Antonio M, Carmignani L, Magni S, Gullotta GS, Lampugnani MG, Iannelli F, Beznoussenko GV, Mironov AA, Cerutti C, Bentley K, Philippides A, Zanardi F, Bacigaluppi M, Sigismund S, Bassani C, Farina C, Martino G, Dejana E, Iannacone M#, Inverso D#, Giannotta M#
June 2024
Plasmacytoid dendritic cells regulate tissue homeostasis of megakaryocytes
Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Guo G, Belz L, Sobirova G, Zhang Z, Titova A, Martinez Navarro A, Pekayvaz K, Lorenz M, von Baumgarten L, Straub T, Popper B, Zheden V, Kaufmann W, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Broker T, Walzog B, Scheiermann C, Aird W,Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendrop RAJ, Iannacone M, Heinig M, Massberg S
May 2024
Preclinical evaluation of therapeutic peptide-glycolipid conjugate vaccines for chronic hepatitis B virus that stimulate antiviral activities of T cells and NKT cells
Mooney AH, Draper SL, Burn OK, Andreson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab S, Painter GF, Hermans IF
February 2024
Priming and maintenance of adaptive immunity in the liver
Kawashima K, Andreata F, Beccaria CG, Iannacone M
2023
December 2023
The lysine demethylase LSD1 controls the balance between inflammatory and antivral responses against coronaviruses
Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilan E, Romanenghi M, Achutti Duso B, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, De Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG
September 2023
Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine
Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Coria L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G
April 2023
SARS-CoV-2 infection causes DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Gioia U, Tavella S, Martinez Orellana P, Cicio G, Colliva A, Paldino A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paladino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d’Adda di Fagagna F
February 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development
Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D
December 2023
Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis
Haberman ER, Sarker G, Arus BA, Ziegler KA, Meunier S, Martinez-Sanchez N, Freibergerova E, Yilmaz-Özcan S, Fernandez-Gonzalez I, Zentai C, O’Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, Lopez M, Ginhoux F, Domingos AI
September 2023
A fluorescent reporter model for the visualization and characterization of TDC
Fiore A, Sala E, Laura C, Riba M, Fumagalli V, Nelli M, Mangione M, Provero P, Oberrauch F, Cristofani C, Iannacone M, Kuka M
March 2023
Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts antiviral adaptive immune responses
Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M
November 2023
IL-1b+ macrophages fuel pathogenic inflammation in pancreatic cancer
Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro E, Ng MSF, Lena MS, Drago D, Andolfo A, Mortellaro A, Corbo V, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R
September 2023
The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling
Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N
March 2023
B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation
Stoler-Barak L, Harris E, Peres A, Hezroni H, Kuka M, Di Lucia P, Grenov A, Gurwicz N, Kupervaser M, Yip BH, Iannacone M, Yaari G, Crispino JD, Shulman Z
2022
December 2022
Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19
Epis S, Varotto-Boccazzi I, Manenti A, Rubolini D, Gabrieli P, Cattaneo GM, Gourlay L, Dapporto F, Monti M, Razzano I, Leonardi M, Iannacone M, Recordati C, Bertola L, Fiorina P, Marvasi L, Montomoli E, Zuccotti GV, Bandi C
July 2022
DNA-vaccine-induced immune response correlates with lower viral SARS-CoV-2 titers in a ferret model
Compagnone M, Pinto E, Salvatori E, Lione L, Conforti A, Marchese S, Ravà M, Ryan K, Hall Y, Rayner E, Salguero J, Paterson J, Iannacone M, De Francesco R, Aurisicchio L*, Palombo F*
June 2022
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype
Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Müller C*, Stein JV*
March 2022
Developing a cure for chronic hepatitis B requires a fresh approach.
Matteo Iannacone and Luca Guidotti
February 2022
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability
Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M
February 2022
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Pekayvaz K, Leunig A, Kaiser R, Brambs S, Joppich M, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wiser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hölscher M, Massberg S, Stark K, Nicolai L
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January 2022
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models
Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M#, Aurisicchio L#
November 2022
Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as potential therapeutic target
Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, Tufano M, Peano C, Iannacone M, Roychoudhuri R, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A
July 2022
Response to contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells
Iannacone M, Bleriot C, Andreata F, Ficht X, Laura C, Garcia-Manteiga JM, Uderhardt S, Ginhoux F
August 2022
Immunological insights in the treatment of chronic hepatitis B
Iannacone M, Andreata F, Guidotti LG
May 2022
Heterogeneity of tissue resident memory T cells
Konjar Š*, Ficht X*, Iannacone M#, Veldhoen M#
January 2022
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M
February 2022
Arenaviral infection causes bleeding in mice due to reduced serotonin release from platelets
Aiolfi R*, Sitia G*, Iannacone M*, Brunetta I, Guidotti LG, Ruggeri ZM
October 2022
Discovery and antiviral profile of new sulfamoylbenzamide derivative as HBV capsid assembly modulators
Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Orsale MV, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R
July 2022
Editorial overview: Viral pathogenesis
Bertoletti A, Iannacone M
April 2022
Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration
Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht M-L, Zhang Z, Kugelmann, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S
March 2022
The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria C, David E, Maier B, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A#, Merad M#, Amit I#
March 2022
Heterogeneity in antiviral B cell responses: Lessons from the movies
Mirela Kuka, Iannacone M
January 2022
Immunobiology and pathogenesis of hepatitis B virus infection
Matteo Iannacone and Luca Guidotti
2021
December 2021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang HD, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria CG... Iannacone M, ..., Yang J
December 2021
Isolation of mouse Kupffer cells for phenotypic and functional studies.
Andreata F, De Simone G, Fumagalli V, Di Lucia P, Ficht X, Beccaria CG, Bleriot C, Kuka M, Ginhoux F, Iannacone M.
August 2021
A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression.
Cilenti F, Barbiera G, Caronni N, Iodice D, Barresi S, Montaldo E, Lusito E, Miotto P, Di Lucia P, Lazarevic D, Cirillo D, Iannacone M, Genua M*, Ostuni R*
October 2021
Repositioning Th cell polarization from single cytokines to complex help.
Tuzlak S, Dejean A, Iannacone M, Quintana F, Waisman A, Ginhoux F, Korn T, Becher B
September 2021
Identification of two subsets of Kupffer cells with distinct functions in liver metabolism.
Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang X-M, Ang N, Shen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell E, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F.
May 2021
IFN signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen.
Baudi I, Isogawa M, Moalli F, Onishi M, Kawashima K, Ito H, Ishikawa T, Wakita T, Iannacone M, Tanaka Y
September 2021
miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance.
Fedeli M, Kuka M, Finardi A, Albano F, Viganò V, Olson EN, Iannacone M, Furlan R, Dellabona P*, Casorati G*
September 2021
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming.
De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M
2020
November 2020
Role of LFA-1 integrin in the control of a lymphocytic choriomeningitis virus (LCMV) infection.
Perro M, Iannacone M, von Andrian UH, Peixoto A.
April 2020
Salivary gland macrophages and tissue-resident CD8+T cells cooperate for homeostatic organ surveillance.
Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV.
September 2020
Immune surveillance of the liver by T cells.
Xenia Ficht and Matteo Iannacone.
March 2020
Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization.
De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M, Iannacone M.
August 2020
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.
Valeria Fumagalli, Pietro Di Lucia, Valentina Venzin, Elisa B. Bono1, Robert Jordan, Christian R. Frey, William Delaney, Francis V. Chisari, Luca G. Guidotti*, and Matteo Iannacone*.
November 2019
CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
May 2019
Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
November 2019
The role of type I interferons in CD4+ T cell differentiation.
Kuka M, De Giovanni M, Iannacone M
October 2019
Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.
Benechet AP*, De Simone G*, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M
2019
2018
November 2018
The conduit system exports locally secreted IgM from lymph nodes.
DeThierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M*, Bajenoff M*
July 2018
Zika virus replication in dorsal root ganglia explants causes myelin degeneration.
Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E
April 2018
Viral subversion of B cell responses within secondary lymphoid organs.
Kuka M, Iannacone M
September 2018
Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity.
Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E
August 2018
Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection.
Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G
April 2018
Intravital imaging of B cell responses in lymph nodes
Sammicheli S, Kuka M, Iannacone M
June 2018
The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ cells
Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV
April 2018
Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node
Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli
February 2018
In vivo imagina of adaptive immune responses to viruses.
De Giovanni M and Iannacone M
2017
December 2017
Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq.
DeMedaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M, Shulman Z, Amit I
November 2017
Sympathetic associated macrophages clear norepinephrine and sustain obesity.
Pirzgalska RM*, Seixas E*, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI
July 2017
Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives viral persistence.
Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G
May 2017
In vivo chronic stimulation unveils intrinsic auto reactive potential of Wiskott-Aldrich syndrome protein-deficient B cells.
Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M
January 2017
Determinants of hepatic effector CD8+ T cell dynamics.
Benechet AP, Iannacone M
November 2017
Migrating platelets are Mechano-scavengers that collect and bundle bacteria.
Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S
November 2017
Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens.
Jimenez de Oya N*, De Giovanni M*, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M
July 2017
Constitutive resistance to viral infection in human CD141+ dendritic cells.
Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N
February 2017
CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperatively to optimize priming.
Brewitz A, Eickhoff S, Dahling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmuller W
November 2017
Intestinal flossing keeps pathogens at bay.
Kuka M and Iannacone M
October 2017
Microcirculation in mouse live lobule: a computational fluir dynamic model based on 3D reconstruction from in vivo microscopy.
Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G
September 2017
Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology.
Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M
January 2017
Intravital microscopy analysis of hepatic T cell dynamics.
Benechet AP, Ganzer K, Iannacone M
2016
May 2016
Platelet-mediated modulation of adaptive immunity.
Iannacone M
January 2016
IFNa gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G
October 2016
Inflammatory monocytes hinder antiviral B cell responses.
Sammicheli S*, Kuka M*, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, De La Torre JC, Guidotti LG, Iannacone M
January 2016
Spatiotemporal dynamics of effector CD8+ T cell responses within the liver.
Inverso D, Iannacone M
September 2016
Protective and pathogenic T cell responses to virus infections.
Iannacone M, Chisari FV, Guidotti LG
2015
April 2015
Immunosurveillance of the liver by intravascular effector CD8+ T cells.
Guidotti LG*, Inverso D*, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez- Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M
January 2015
A luminescent poly(amidoamine)-iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy.
Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G
November 2015
Mouse models of HBV pathogenesis.
Iannacone M, Guidotti LG
May 2015
Hepatic effector CD8+ T cell dynamics.
Iannacone M
November 2015
Viral pathogenesis.
Iannacone M, Guidotti LG
2014
April 2014
PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M
June 2014
The role of lymph node sinus macrophages in host defense.
Kuka M, Iannacone M
December 2014
In vivo flow mapping in complex vessel networks by single image correlation
Sironi L, Bouzin M, Inverso D, D'Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G
May 2014
Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.
Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Jhonston LP, Kishimoto TK
October 2013
Biophosphonates target B cells to enhance humoral immune responses.
Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M
August 2013
Effector CD8 T cell trafficking within the liver
Guidotti LG, Iannacone M
September 2013
Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions.
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, Von Andrian UH
November 2013
Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.
Sitia G, Iannacone M, Guidotti LG
2013
2012
September 2012
Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes.
Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, Von Andrian UH
April 2012
Follicular helper NKT cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+T cells.
Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G,
August 2012
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG
March 2012
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH