2020
March 2020
Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization.
De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M, Iannacone M.
November 2019
CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
May 2019
Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
November 2019
The role of type I interferons in CD4+ T cell differentiation.
Kuka M, De Giovanni M, Iannacone M
October 2019
Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.
Benechet AP*, De Simone G*, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M
2019
2018
November 2018
The conduit system exports locally secreted IgM from lymph nodes.
DeThierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M*, Bajenoff M*
July 2018
Zika virus replication in dorsal root ganglia explants causes myelin degeneration.
Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E
April 2018
Viral subversion of B cell responses within secondary lymphoid organs.
Kuka M, Iannacone M
September 2018
Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity.
Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E
August 2018
Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction in mice and is safe and effective during acute viral infection.
Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G
April 2018
Intravital imaging of B cell responses in lymph nodes
Sammicheli S, Kuka M, Iannacone M
June 2018
The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ cells
Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV
April 2018
Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node
Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli
February 2018
In vivo imagina of adaptive immune responses to viruses.
De Giovanni M and Iannacone M
2017
December 2017
Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq.
DeMedaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M, Shulman Z, Amit I
November 2017
Sympathetic associated macrophages clear norepinephrine and sustain obesity.
Pirzgalska RM*, Seixas E*, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI
July 2017
Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives viral persistence.
Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G
May 2017
In vivo chronic stimulation unveils intrinsic auto reactive potential of Wiskott-Aldrich syndrome protein-deficient B cells.
Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M
January 2017
Determinants of hepatic effector CD8+ T cell dynamics.
Benechet AP, Iannacone M
November 2017
Migrating platelets are Mechano-scavengers that collect and bundle bacteria.
Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S
November 2017
Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens.
Jimenez de Oya N*, De Giovanni M*, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M
July 2017
Constitutive resistance to viral infection in human CD141+ dendritic cells.
Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N
February 2017
CD8+ T cells orchestrate pDC-XCR1+ dendritic cell spatial and functional cooperatively to optimize priming.
Brewitz A, Eickhoff S, Dahling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmuller W
November 2017
Intestinal flossing keeps pathogens at bay.
Kuka M and Iannacone M
October 2017
Microcirculation in mouse live lobule: a computational fluir dynamic model based on 3D reconstruction from in vivo microscopy.
Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G
September 2017
Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology.
Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M
January 2017
Intravital microscopy analysis of hepatic T cell dynamics.
Benechet AP, Ganzer K, Iannacone M
2016
May 2016
Platelet-mediated modulation of adaptive immunity.
Iannacone M
January 2016
IFNa gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment.
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G
October 2016
Inflammatory monocytes hinder antiviral B cell responses.
Sammicheli S*, Kuka M*, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, De La Torre JC, Guidotti LG, Iannacone M
January 2016
Spatiotemporal dynamics of effector CD8+ T cell responses within the liver.
Inverso D, Iannacone M
September 2016
Protective and pathogenic T cell responses to virus infections.
Iannacone M, Chisari FV, Guidotti LG
2015
April 2015
Immunosurveillance of the liver by intravascular effector CD8+ T cells.
Guidotti LG*, Inverso D*, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez- Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M
January 2015
A luminescent poly(amidoamine)-iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy.
Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G
November 2015
Mouse models of HBV pathogenesis.
Iannacone M, Guidotti LG
May 2015
Hepatic effector CD8+ T cell dynamics.
Iannacone M
November 2015
Viral pathogenesis.
Iannacone M, Guidotti LG
2014
April 2014
PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner.
Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M
June 2014
The role of lymph node sinus macrophages in host defense.
Kuka M, Iannacone M
December 2014
In vivo flow mapping in complex vessel networks by single image correlation
Sironi L, Bouzin M, Inverso D, D'Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G
May 2014
Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.
Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Jhonston LP, Kishimoto TK
October 2013
Biophosphonates target B cells to enhance humoral immune responses.
Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M
August 2013
Effector CD8 T cell trafficking within the liver
Guidotti LG, Iannacone M
September 2013
Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions.
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, Von Andrian UH
November 2013
Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma.
Sitia G, Iannacone M, Guidotti LG
2013
2012
September 2012
Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes.
Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, Von Andrian UH
April 2012
Follicular helper NKT cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+T cells.
Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G,
August 2012
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG
March 2012
B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity.
Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH