2024
July 2024
Therapeutic potential of co-signaling receptor modulation in hepatitis B
Andreata F, Krueger CC, Laura C, Ravà M, Ficht X, Kawashima K, Beccaria CG, Moalli F, Partini B, Fumagalli V, Nosetto G, Di Lucia P, Montali I, Garcia-Manteiga JM, Bono EB, Giustini L, Perucchini C, Venzin V, Ranucci S, Inverso D, De Giovanni M, Genua M, Ostuni R, Lugli E, Isogawa M, Ferrari C, Boni C, Fisicaro P, Guidotti LG, Iannacone M
March 2024
Antibody-independent protection against heterologous SARS-CoV-2 challenge conferred by prior infection or vaccination
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Bono EB, Giustini L, De Leo F, Casalgrandi M, Monteleone E, Mouro V, Malpighi C, Perucchini C, Grillo M, De Palma S, Donnici L, Marchese S, Conti M, Muramatsu H, Perlman S, Pardi N, Kuka M, De Francesco R, Bianchi ME, Guidotti LG, Iannacone M
January 2024
Deterministic reprogramming of neutrophils within tumors
Ng MSF, Kwok I, Tan L, Shi C, Cerezo-Wallis D, Tan Y, Leong K, Calvo GF, Yang K, Zhang Y, Jing J, Liong KH, Wu D, He R, Liu D, Teh YC, Bleriot C, Caronni N, Moalli F, Liu Z, Duan K, Narang V, Ballesteros I, Li M, Chen J, Liu Y, Liu L, Qi J, Liu Y, Jiang L, Shen B, Cheng H, Cheng T, Angeli V, Sharma A, Loh Y-H, Tey HL, Chong SH, Iannacone M, Ostuni R, Hidalgo A, Ginhoux F, Ng LG
August 2024
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness
Pallavicini I, Frasconi T, Catozzi C, Tiberti S, Ceccaci E, Hass D, Samson J, Heuser C, Nava Lauson CB, Mangione M, Preto E, Bigogno A, Sala E, Iannacone M, Gattinoni L, Caruana I, Kuka M, Nezi L, Minucci S, Manzo T
May 2024
Highlights from the 2023 International Meeting on the Molecular Biology of Hepatitis B virus
HBV2023, Allweiss L, Cohen C, Dias J, Fumagalli V, Guo H, Harris JM, Hu J, Iannacone M, Isogawa M, Jeng W-J, Kim K-H, Kramvis A, Li W, Lucifora J, Muramatsu M, Neuveut C, Ploss A, Pollicino T, Protzer U, Tan A, Tanaka Y, Tu T, Tsukuda S, Thimme R, Urban S, Watashi K, Yuan Z, Yeh S-H, McKeating JA, Revill PA
August 2024
Gpr126 is a crucial regulator of blood-brain barrier maturation and function
Kakogiannos N, Scalise AA, Martini E, Maderna C, Benvenuto AF, D’Antonio M, Carmignani L, Magni S, Gullotta GS, Lampugnani MG, Iannelli F, Beznoussenko GV, Mironov AA, Cerutti C, Bentley K, Philippides A, Zanardi F, Bacigaluppi M, Sigismund S, Bassani C, Farina C, Martino G, Dejana E, Iannacone M#, Inverso D#, Giannotta M#
June 2024
Plasmacytoid dendritic cells regulate tissue homeostasis of megakaryocytes
Gaertner F, Ishikawa-Ankerhold H, Stutte S, Fu W, Weitz J, Dueck A, Nelakuditi B, Fumagalli V, van den Heuvel D, Guo G, Belz L, Sobirova G, Zhang Z, Titova A, Martinez Navarro A, Pekayvaz K, Lorenz M, von Baumgarten L, Straub T, Popper B, Zheden V, Kaufmann W, von Stillfried S, Boor P, Colonna M, Clauß S, Schulz C, Broker T, Walzog B, Scheiermann C, Aird W,Nerlov C, Stark K, Petzold T, Engelhardt S, Sixt M, Hauschild R, Rudelius M, Oostendrop RAJ, Iannacone M, Heinig M, Massberg S
May 2024
Preclinical evaluation of therapeutic peptide-glycolipid conjugate vaccines for chronic hepatitis B virus that stimulate antiviral activities of T cells and NKT cells
Mooney AH, Draper SL, Burn OK, Andreson RJ, Compton BJ, Tang C, Farrand KJ, Di Lucia P, Ravà M, Fumagalli V, Giustini L, Bono E, Godfrey DI, Heath WR, Yuan W, Chisari FV, Guidotti LG, Iannacone M, Sidney J, Sette A, Gulab S, Painter GF, Hermans IF
2023
December 2023
The lysine demethylase LSD1 controls the balance between inflammatory and antivral responses against coronaviruses
Mazzarella L, Santoro F, Ravasio R, Fumagalli V, Massa PE, Rodighiero S, Gavilan E, Romanenghi M, Achutti Duso B, Bonetti E, Manganaro L, Pallavi R, Trastulli D, Pallavicini I, Gentile C, Monzani S, Leonardi T, Pasqualato S, Buttinelli G, Di Martino A, Fedele G, Schiavoni I, Stefanelli P, Meroni G, De Francesco R, Steinkuhler C, Fossati G, Iannacone M, Minucci S, Pelicci PG
September 2023
Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine
Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Coria L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G
April 2023
SARS-CoV-2 infection causes DNA damage, through CHK1 degradation and impaired 53BP1 recruitment, and cellular senescence
Gioia U, Tavella S, Martinez Orellana P, Cicio G, Colliva A, Paldino A, Ceccon M, Cabrini M, Henriques AC, Fumagalli V, Paladino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe MC, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A, d’Adda di Fagagna F
February 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development
Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D
December 2023
Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis
Haberman ER, Sarker G, Arus BA, Ziegler KA, Meunier S, Martinez-Sanchez N, Freibergerova E, Yilmaz-Özcan S, Fernandez-Gonzalez I, Zentai C, O’Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, Lopez M, Ginhoux F, Domingos AI
March 2023
Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts antiviral adaptive immune responses
Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M
November 2023
IL-1b+ macrophages fuel pathogenic inflammation in pancreatic cancer
Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro E, Ng MSF, Lena MS, Drago D, Andolfo A, Mortellaro A, Corbo V, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M, Ostuni R
September 2023
The guanine nucleotide exchange factor Rin-like acts as a gatekeeper for T follicular helper cell differentiation via regulating CD28 signaling
Sandner L, Alteneder M, Rica R, Woller B, Sala E, Frey T, Tosevska A, Zhu C, Madern M, Khan M, Hoffmann P, Schebesta A, Taniuchi I, Bonelli M, Schmetterer K, Iannacone M, Kuka M, Ellmeier W, Sakaguchi S, Herbst R, Boucheron N
2022
December 2022
Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-19
Epis S, Varotto-Boccazzi I, Manenti A, Rubolini D, Gabrieli P, Cattaneo GM, Gourlay L, Dapporto F, Monti M, Razzano I, Leonardi M, Iannacone M, Recordati C, Bertola L, Fiorina P, Marvasi L, Montomoli E, Zuccotti GV, Bandi C
June 2022
Microbial uptake in oral mucosa–draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype
Barreto de Albuquerque J, Altenburger LM, Abe J, von Werdt D, Wissmann S, Magdaleno JM, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Müller C*, Stein JV*
February 2022
Group 1 ILCs regulate T cell–mediated liver immunopathology by controlling local IL-2 availability
Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M
February 2022
Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
Pekayvaz K, Leunig A, Kaiser R, Brambs S, Joppich M, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deak F, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wiser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hölscher M, Massberg S, Stark K, Nicolai L
January 2022
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models
Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M#, Aurisicchio L#
November 2022
Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defines hyperactivated Tregs as potential therapeutic target
Alvisi G, Termanini A, Soldani C, Portale F, Carriero R, Pilipow K, Polidoro M, Franceschini B, Malenica I, Puccio S, Lise V, Galletti G, Zanon V, Colombo FS, Tufano M, Peano C, Iannacone M, Roychoudhuri R, Donadon M, Torzilli G, Kunderfranco P, Di Mitri D, Lugli E, Lleo A
January 2022
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion
Fumagalli V, Ravà M, Marotta D, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M
October 2022
Discovery and antiviral profile of new sulfamoylbenzamide derivative as HBV capsid assembly modulators
Ivanova Bencheva L, Donnici L, Ferrante L, Prandi A, Sinisi R, De Matteo M, Randazzo P, Conti M, Di Lucia P, Bono E, Giustini L, Orsale MV, Patsilinakos A, Monteagudo E, Iannacone M, Summa V, Guidotti LG, De Francesco R, Di Fabio R
April 2022
Thrombocytopenia and splenic platelet directed immune responses after intravenous ChAdOx1 nCov-19 administration
Nicolai L, Leunig A, Pekayvaz K, Esefeld M, Anjum A, Rath J, Riedlinger E, Ehreiser V, Mader M, Eivers L, Hoffknecht M-L, Zhang Z, Kugelmann, Rossaro D, Escaig R, Kaiser R, Polewka V, Titova A, Petzold T, Spiekermann K, Iannacone M, Thiele T, Greinacher A, Stark K, Massberg S
March 2022
The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
Cohen M, Giladi A, Barboy O, Hamon P, Li B, Zada M, Gurevich-Shapiro A, Beccaria C, David E, Maier B, Buckup M, Kamer I, Deczkowska A, Le Berichel J, Bar J, Iannacone M, Tanay A#, Merad M#, Amit I#
2021
December 2021
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza A, Chang HD, Radbruch A, Abrignani S, Addo R, Akdis M, Andrä I, Andreata F, Annunziato F, Arranz E, Bacher P, Bari S, Barnaba V, Barros-Martins J, Baumjohann D, Beccaria CG... Iannacone M, ..., Yang J
September 2021
Identification of two subsets of Kupffer cells with distinct functions in liver metabolism.
Bleriot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang X-M, Ang N, Shen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell E, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F.
September 2021
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming.
De Simone G, Andreata F, Bleriot C, Fumagalli V, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F, Iannacone M
2020
April 2020
Salivary gland macrophages and tissue-resident CD8+T cells cooperate for homeostatic organ surveillance.
Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV.
November 2019
CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
May 2019
Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates.
De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E
October 2019
Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.
Benechet AP*, De Simone G*, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M
2019
2018
June 2018
The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ cells
Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV
2017
November 2017
Sympathetic associated macrophages clear norepinephrine and sustain obesity.
Pirzgalska RM*, Seixas E*, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI
November 2017
Migrating platelets are Mechano-scavengers that collect and bundle bacteria.
Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S
November 2017
Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens.
Jimenez de Oya N*, De Giovanni M*, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M
July 2017
Constitutive resistance to viral infection in human CD141+ dendritic cells.
Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N
2016
2015
April 2015
Immunosurveillance of the liver by intravascular effector CD8+ T cells.
Guidotti LG*, Inverso D*, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez- Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M
2014
May 2014
Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.
Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Jhonston LP, Kishimoto TK
September 2013
Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions.
Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, Von Andrian UH
2013
2012