Our research program seeks to dissect the complex dynamics of host-virus interactions with a particular focus on the development and function of adaptive immune responses. Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical, cellular, biochemical, and other factors that influence cell behavior in microvessels and interstitial tissues, we make use of intravital microscopy. This technique is complemented by more traditional molecular, cellular and histological approaches, thus characterizing host-virus interactions at the molecular-, single cell- and whole animal-level.
To characterize how viruses are handled within draining lymph-nodes upon peripheral inoculation and how antiviral immune responses are generated;
To dissect the pathogenetic mechanisms underlying liver immunopathology during viral hepatitis using intravital microscopy;
To discover and characterize novel adjuvants for adaptive immune responses.